US 11,746,133 B2
Cell penetrating peptides that inhibit IRF5 nuclear localization
Betsy J. Barnes, Glenwood Landing, NY (US)
Assigned to Rutgers, The State University of New Jersey, New Brunswick, NJ (US)
Filed by Rutgers, The State University of New Jersey, New Brunswick, NJ (US)
Filed on Sep. 13, 2021, as Appl. No. 17/472,760.
Application 16/570,291 is a division of application No. 15/758,276, abandoned, previously published as PCT/US2016/051114, filed on Sep. 9, 2016.
Application 17/472,760 is a continuation of application No. 16/570,291, filed on Sep. 13, 2019, granted, now 11,130,790.
Claims priority of provisional application 62/215,896, filed on Sep. 9, 2015.
Prior Publication US 2021/0403520 A1, Dec. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/08 (2019.01); A61K 38/16 (2006.01); A61K 38/00 (2006.01); A61P 37/02 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01); C07K 14/00 (2006.01)
CPC C07K 14/4702 (2013.01) [A61P 37/02 (2018.01); A61K 38/00 (2013.01); C07K 2319/09 (2013.01); C07K 2319/10 (2013.01)] 11 Claims
 
1. A polypeptide comprising a cell penetrating peptide sequence and an amino-terminus interferon regulatory factor 5 (IRF5) nuclear localization signal (NLS) sequence;
wherein the cell penetrating peptide sequence is selected from the group consisting of
 
 (SEQ ID NO: 5)
 
 DRQIKIWFQNRRMKWKK,
 
 
 
 (SEQ ID NO: 9)
 
 AAVALLPAVLLALLAP,
 
 
 
 (SEQ ID NO: 10)
 
 GRKKRRQRRRPPQ,
 
 
 
 (SEQ ID NO: 11)
 
 CSIPPEVKFNKPFVYLI,
 
 
 
 (SEQ ID NO: 12)
 
 KKWKMRRNQFWVKVQRG,
 
 
 
 (SEQ ID NO: 13)
 
 KLLKLLLKLWLKLLKLLL,
 
 
 
 (SEQ ID NO: 14)
 
 INLKALAALAKKIL,
 
 
 
 (SEQ ID NO: 15)
 
 RQIKIWFQNRRMKWKKGG
 
 and
 
 
 
 (SEQ ID NO: 16)
 
 GWTLNSAGYLLGKINLKALAALAKKIL;
and
wherein the amino-terminus interferon regulatory factor 5 (IRF5) nuclear localization signal (NLS) sequence is PRRVRLK (SEQ ID NO:1).