CPC C07D 491/18 (2013.01) [C07K 1/067 (2013.01)] | 25 Claims |
1. A protecting group for protecting a cysteine residue, the protecting group having structural formula 11 or 12:
wherein
R is an electron withdrawing group or a leaving group;
Ar is optionally substituted aryl or optionally substituted heteroaryl;
X, Y, Z and Z1 are independently of each other oxygen, sulfur, nitrogen or phosphorus;
R1 and R2 are independently of each other hydrogen, hydroxyl, halo, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, formyl, haloformyl, carbonyl, carboxyl, alkoxy, alkoxycarbonyl, (alkoxycarbonyl)oxy, carbamoyl, amino, amido, imino, imido, azo, cyanato, isocyanato, cyano, nitro, sulfanyl, thiocyanato or phosphono, each of which is optionally substituted; and
n and n1 are independently of each other an integer between 1 and 12, inclusive.
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