US 11,746,111 B2
Siderophore conjugated pyrazolidinones, and analogues thereof
Mark Plummer, Westbrook, CT (US); Denton Hoyer, West Haven, CT (US); and Elizabeth Spencer, Southbury, CT (US)
Assigned to YALE UNIVERSITY, New Haven, CT (US)
Appl. No. 17/260,856
Filed by YALE UNIVERSITY, New Haven, CT (US)
PCT Filed Jul. 19, 2019, PCT No. PCT/US2019/042643
§ 371(c)(1), (2) Date Jan. 15, 2021,
PCT Pub. No. WO2020/018929, PCT Pub. Date Jan. 23, 2020.
Claims priority of provisional application 62/701,249, filed on Jul. 20, 2018.
Prior Publication US 2021/0269449 A1, Sep. 2, 2021
Int. Cl. C07D 487/04 (2006.01); A61P 31/04 (2006.01); A61K 9/00 (2006.01); A61K 31/427 (2006.01); A61K 31/4439 (2006.01)
CPC C07D 487/04 (2013.01) [A61K 9/0019 (2013.01); A61K 31/427 (2013.01); A61K 31/4439 (2013.01); A61P 31/04 (2018.01)] 17 Claims
OG exemplary drawing
 
1. A compound of formula (I), or a salt, solvate, enantiomer, diastereoisomer, tautomer, or geometric isomer thereof:

OG Complex Work Unit Chemistry
wherein:
R1 is selected from the group consisting of:

OG Complex Work Unit Chemistry
X is selected from the group consisting of CH, CF, CCl, and N;
Y is selected from the group consisting of:

OG Complex Work Unit Chemistry
Z is a divalent group selected from the group consisting of —NH—, —NMe-, —O—, and —S—; and
Q is a siderophore or a siderophore mimic.