CPC C07D 407/14 (2013.01) [A61K 31/351 (2013.01); A61K 31/365 (2013.01); A61P 25/28 (2018.01); A61P 31/18 (2018.01); A61P 35/00 (2018.01); C07D 493/22 (2013.01)] | 3 Claims |
1. A bryostatin analog having the formula (XXXI):
wherein:
R4 is an alkyl or a substituted alkyl;
Z2 is CR5R6 or NR7 when the covalent bond designated “b” is a double bond;
Z2 is OR8 or N(R7)2 when the covalent bond designated “b” is a single bond;
R5 is alkyloxycarbonyl, substituted alkyloxycarbonyl, alkyl or substituted alkyl;
R6, R7 and R8 are each independently H, alkyloxycarbonyl, substituted alkyloxycarbonyl, alkyl or substituted alkyl;
R11 is a substituted acyl, an alkyl or a substituted alkyl;
R12 is H, an alkyl or a substituted alkyl;
R13 is H, an alkyl or a substituted alkyl; and
R14 and R15 are independently H, a hydroxyl protecting group or a promoiety;
or a solvate, hydrate or prodrug form thereof and/or a salt thereof.
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