	US 11,746,094 B2
	Small molecule photosensitizers for photodynamic therapy
Marc Vendrell, Edinburgh (GB); Antonio Fernandez, Edinburgh (GB); Sam Benson, Edinburgh (GB); Nicole D. Barth, Edinburgh (GB); and Fabio De Moliner, Edinburgh (GB)
Assigned to The University Court of the University of Edinburgh, Edinburgh (GB)
Appl. No. 17/439,069
Filed by The University Court of the University of Edinburgh, Edinburgh (GB)
PCT Filed Mar. 17, 2020, PCT No. PCT/EP2020/057300 § 371(c)(1), (2) Date Sep. 14, 2021, PCT Pub. No. WO2020/187913, PCT Pub. Date Sep. 24, 2020.
Claims priority of application No. 1903671 (GB), filed on Mar. 18, 2019.
Prior Publication US 2022/0153714 A1, May 19, 2022
Int. Cl. A61K 41/00 (2020.01); C07D 293/12 (2006.01); C07D 421/04 (2006.01)

CPC C07D 293/12 (2013.01) [A61K 41/0057 (2013.01); C07D 421/04 (2013.01)]

16 Claims

1. A method of treating a disease in a metabolically active cell, using targeted photodynamic therapy, wherein the method comprises:

a) providing to the metabolically-active cell a compound of formula (I)

or a derivative or a salt thereof; and

b) activating the compound with visible light, resulting in singlet oxygen generation and concomitant cell death;

wherein

R1 is selected from the group consisting of amines, anilines, phenols, thiophenols, selenols and aryl groups;

R2 and R3 independently are H or halogen;

R4 is nitro; and

R5 and R6 independently are either absent or oxygen or methyl.