CPC C07D 209/10 (2013.01) [A61K 49/006 (2013.01); A61K 49/0032 (2013.01); A61K 49/0058 (2013.01); C07D 403/12 (2013.01); C09K 11/06 (2013.01); G01N 21/6428 (2013.01); G01N 33/533 (2013.01); G01N 33/582 (2013.01); G01N 2021/6439 (2013.01)] | 19 Claims |
1. A conjugate or conjugate precursor, or stereoisomer thereof, according to Formula I:
wherein m is 3, 4, or 5;
n is 1, 2, or 3;
each p independently is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10;
R1 is —CR22— where each R2 independently is H, halo, optionally substituted aliphatic, or optionally substituted aryl;
R3 and R4 independently are aliphatic;
R5 to R10 independently are H or aliphatic;
R11 and R12 independently are a sulfonate-containing group;
R13 to R16 independently are aliphatic;
Ra is —(R1)qC(O)Rc where q is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10;
each Rb independently is C1-C5 aliphatic; and
Rc is a targeting agent-containing group,
where y is an integer≥1, or —OH, wherein the targeting agent is an antibody, a peptide, a protein, an amino acid, a nucleoside, a nucleotide, a nucleic acid, an oligonucleotide, a carbohydrate, a lipid, a hapten, or a receptor ligand.
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