US 11,745,180 B2
Microfluidic systems, pumps, valves, fluidic chips thereof, and applications of same
Ronald S. Reiserer, Nashville, TN (US); David K. Schaffer, Nashville, TN (US); Philip C. Samson, Nashville, TN (US); Dmitry A. Markov, Nashville, TN (US); Michael Geuy, Nashville, TN (US); Lisa J. McCawley, Nashville, TN (US); and John P. Wikswo, Brentwood, TN (US)
Assigned to VANDERBILT UNIVERSITY, Nashville, TN (US)
Filed by VANDERBILT UNIVERSITY, Nashville, TN (US)
Filed on Dec. 20, 2022, as Appl. No. 18/84,634.
Application 18/084,634 is a continuation of application No. 17/623,350, granted, now 11,565,256, previously published as PCT/US2020/040061, filed on Jun. 29, 2020.
Application 17/623,350 is a continuation in part of application No. PCT/US2019/047324, filed on Aug. 20, 2019.
Application PCT/US2019/047324 is a continuation in part of application No. PCT/US2019/047307, filed on Aug. 20, 2019.
Application PCT/US2019/047307 is a continuation in part of application No. PCT/US2019/047190, filed on Aug. 20, 2019.
Claims priority of provisional application 62/868,303, filed on Jun. 28, 2019.
Prior Publication US 2023/0122594 A1, Apr. 20, 2023
Int. Cl. B01L 3/00 (2006.01); F04B 43/12 (2006.01); F16K 11/16 (2006.01)
CPC B01L 3/502738 (2013.01) [B01L 2300/0627 (2013.01); B01L 2300/123 (2013.01); B01L 2400/0644 (2013.01); F04B 43/1261 (2013.01); F16K 11/163 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A microfluidic system, being a tilted-actuator pump, and comprising:
a support plate;
a fluidic chip disposed on the support plate, wherein the fluidic chip has a fluidic network comprising at least one fluidic channel;
an actuator having a plurality of compression structures configured to roll against the fluidic chip to control the fluidic channel to switch between an open state and a closed state, wherein each of the compression structures is a roller; and
a motor shaft inserted in the actuator to drive the actuator to rotate relative to the fluidic chip;
wherein the actuator and the motor shaft are disposed to tilt from an actuator-contact surface of the fluidic chip, such that the actuator rotates in a plane tilted by an angle with respect to the actuator-contact surface of the fluidic chip.