US 11,744,926 B2
Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications
Sarah Mayes, Austin, TX (US); and Christine E. Schmidt, Gainesville, FL (US)
Assigned to Board Of Regents, The University Of Texas System, Austin, TX (US)
Filed by Board Of Regents, The University Of Texas System, Austin, TX (US)
Filed on Jul. 7, 2021, as Appl. No. 17/369,067.
Application 17/369,067 is a continuation of application No. 16/400,259, filed on May 1, 2019, granted, now 11,058,802.
Application 16/400,259 is a continuation of application No. 15/596,685, filed on May 16, 2017, granted, now 10,314,950, issued on Jun. 11, 2019.
Application 15/596,685 is a continuation of application No. 14/803,258, filed on Jul. 20, 2015, granted, now 9,656,001, issued on May 23, 2017.
Application 14/803,258 is a continuation of application No. 13/269,344, filed on Oct. 7, 2011, granted, now 9,095,558, issued on Aug. 4, 2015.
Claims priority of provisional application 61/391,299, filed on Oct. 8, 2010.
Prior Publication US 2021/0338906 A1, Nov. 4, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 31/04 (2006.01); A61K 31/195 (2006.01); A61L 31/14 (2006.01); A61K 31/192 (2006.01); A61L 31/16 (2006.01)
CPC A61L 31/041 (2013.01) [A61K 31/192 (2013.01); A61K 31/195 (2013.01); A61L 31/145 (2013.01); A61L 31/148 (2013.01); A61L 31/16 (2013.01); A61L 2300/414 (2013.01); A61L 2300/43 (2013.01); A61L 2300/62 (2013.01)] 20 Claims
 
1. An apparatus comprising:
a desiccated, amorphous, translucent, hydrogel film including:
a first film layer comprising uncrosslinked hyaluronic acid and alginate that is negatively charged and crosslinked with at least one cation; and
a second film layer comprising uncrosslinked hyaluronic acid and alginate that is negatively charged and crosslinked with the at least one cation;
wherein (a) the first film layer is fused to the second film layer; and (b) the first film layer is anti-adhesive and non-attractive to cells and the second film layer is adhesive to cells.