	US 11,744,922 B2
	Biomimetic sponges for tissue regeneration
Koyal Garg, St. Louis, MO (US); and Gabriel Haas, St. Louis, MO (US)
Assigned to Saint Louis University, St. Louis, MO (US)
Filed by Saint Louis University, St. Louis, MO (US)
Filed on Oct. 29, 2018, as Appl. No. 16/173,459.
Claims priority of provisional application 62/577,815, filed on Oct. 27, 2017.
Prior Publication US 2019/0151513 A1, May 23, 2019
Int. Cl. A61L 27/56 (2006.01); A61L 27/58 (2006.01); A61L 27/26 (2006.01); A61L 27/54 (2006.01); A61L 27/24 (2006.01); A61L 27/22 (2006.01); A61K 38/18 (2006.01); A61L 27/38 (2006.01); A61L 27/52 (2006.01); A61L 27/32 (2006.01); A61L 27/46 (2006.01)

CPC A61L 27/56 (2013.01) [A61K 38/1825 (2013.01); A61K 38/1875 (2013.01); A61L 27/222 (2013.01); A61L 27/24 (2013.01); A61L 27/3804 (2013.01); A61L 27/54 (2013.01); A61L 27/26 (2013.01); A61L 27/32 (2013.01); A61L 27/46 (2013.01); A61L 27/52 (2013.01); A61L 27/58 (2013.01); A61L 2300/414 (2013.01)]

19 Claims

1. A biomimetic sponge comprising a homogenous mixture of gelatin, collagen, and laminin-111 crosslinked with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide, wherein the ratio of gelatin to collagen ranges from about 99 wt. % gelatin to about 1 wt. % collagen to about 96 wt. % gelatin to about 4 wt. % collagen, the amount of laminin ranges from about 0.04 wt. % to about 2 wt. %, and the crosslinking results in a degradation rate ranging from about 2 weeks to about 4 weeks.