US 11,744,916 B2
Radiopaque polymers
Koorosh Ashrafi, Purley (GB); Hugh Britton, Gillingham (GB); Francesco Cuda, Basingstoke (GB); Andrew Lennard Lewis, Farnham (GB); Cristian Parisi, London (GB); Yiqing Tang, Guildford (GB); and Sean Leo Willis, Farnham (GB)
Assigned to Biocompatibles UK Limited
Filed by BIOCOMPATIBLES UK LIMITED, Farnham (GB)
Filed on Jul. 20, 2020, as Appl. No. 16/933,042.
Claims priority of application No. 19102862 (GB), filed on Jul. 18, 2019.
Prior Publication US 2021/0015963 A1, Jan. 21, 2021
Int. Cl. C08G 81/00 (2006.01); A61L 24/06 (2006.01); C07D 405/04 (2006.01); C08F 216/10 (2006.01)
CPC A61L 24/06 (2013.01) [C07D 405/04 (2013.01); C08F 216/10 (2013.01); A61L 2430/36 (2013.01)] 22 Claims
 
1. A polymer comprising polyvinyl alcohol (PVA), the PVA having a first pendant group and a second pendant group, wherein the first pendant group comprises a first phenyl group bearing 1 to 5 iodines as the sole substituent(s) of the first phenyl group, and wherein the second pendant group comprises a second phenyl group bearing 1 to 3 substituents selected from the group W and optionally 1 to 4 iodine substituents, the group(s) W and the optional iodines being the sole substituents of the second phenyl group;
wherein each W is independently selected from —SO3H, —OPO3H2, and —O—(C1-4alkyl)R2,
wherein R2 is —SO3H, or
—OPO3H2; and wherein the group W may be in the form of a pharmaceutically acceptable salt.