| US 11,744,915 B2 | ||
| Diagnostic device | ||
| Mikhail L. Pekurovsky, Bloomington, MN (US); Matthew S. Stay, Bloomington, MN (US); Hannah J. Loughlin, Mahtomedi, MN (US); Kevin T. Reddy, Minneapolis, MN (US); Henrik B. Van Lengerich, St. Paul, MN (US); Ann M. Gilman, Bayport, MN (US); and Matthew R.D. Smith, Woodbury, MN (US) | ||
| Assigned to 3M INNOVATIVE PROPERTIES COMPANY, St. Paul, MN (US) | ||
| Appl. No. 17/906,704 | ||
| Filed by 3M INNOVATIVE PROPERTIES COMPANY, St. Paul, MN (US) | ||
|
PCT Filed Mar. 16, 2021, PCT No. PCT/IB2021/052179 § 371(c)(1), (2) Date Sep. 19, 2022, PCT Pub. No. WO2021/198827, PCT Pub. Date Oct. 7, 2021. |
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| Claims priority of provisional application 63/003,169, filed on Mar. 31, 2020. | ||
| Prior Publication US 2023/0120911 A1, Apr. 20, 2023 | ||
| Int. Cl. A61L 15/58 (2006.01); B01L 3/00 (2006.01) | ||
| CPC A61L 15/58 (2013.01) [B01L 3/5023 (2013.01); B01L 3/502738 (2013.01)] | 20 Claims |
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1. A diagnostic device, comprising:
an elongate substantially planar porous substrate with a first end and a second end, wherein the substrate comprises at least one folded region between the first end and the second end, and wherein:
a first portion of the substrate lies in a first plane with respect to the folded region, wherein the first portion of the substrate comprises a first hydrophobic region and a first hydrophilic region, wherein the first hydrophobic region comprises a first low surface energy polymeric material extending from a first major surface of the first portion of the substrate to a second major surface of the first portion of the substrate, and wherein the first hydrophobic region comprises an arrangement of interconnected open pores providing at least one uninterrupted path extending from the first major surface of the first portion of the substrate to the second major surface of the first portion of the substrate; and
a second portion of the substrate that lies in a second plane with respect to the folded region, wherein the second plane is substantially parallel to the first plane, the second portion of the substrate comprising a second hydrophilic region and a second hydrophobic region comprising a second low surface energy polymeric material, which may be the same or different from the first low surface energy polymeric material, extending from a first major surface of the second portion of the substrate to second major surface of the second portion of the substrate, and wherein the second hydrophobic region comprises an arrangement of interconnected open pores providing at least one uninterrupted path extending from the first major surface of the second portion of the substrate to the second major surface of the second portion of the substrate;
at least one connective region between the first portion of the substrate and the second portion of the substrate, wherein the at least one connective region is configured to maintain alignment of the first hydrophilic region and the second hydrophilic region sufficient to provide a sample flow path between the first portion of the substrate and the second portion of the substrate along a direction normal to the first plane and the second plane; and a reagent along the sample flow path, wherein the reagent is selected to detect at least one of a presence, an absence or a concentration of an analyte present in a sample applied to the diagnostic device. |