	US 11,744,901 B2
	Phage conjugates and uses thereof
Piergiuseppe De Berardinis, Rome (IT); and Rossella Sartorius, Rome (IT)
Assigned to CONSIGLIO NAZIONALE DELLE RICERCHE, Rome (IT)
Appl. No. 16/478,338
Filed by CONSIGLIO NAZIONALE DELLE RICERCHE, Pomezia (IT)
PCT Filed Jan. 29, 2018, PCT No. PCT/IB2018/050525 § 371(c)(1), (2) Date Jul. 16, 2019, PCT Pub. No. WO2018/138696, PCT Pub. Date Aug. 2, 2018.
Claims priority of application No. 102017000009270 (IT), filed on Jan. 27, 2017.
Prior Publication US 2019/0343965 A1, Nov. 14, 2019
Int. Cl. A61K 47/69 (2017.01); A61P 35/00 (2006.01); A61K 39/39 (2006.01); C07K 14/52 (2006.01); C07K 14/77 (2006.01); C07K 16/28 (2006.01); C12N 7/00 (2006.01); A61K 39/00 (2006.01)

CPC A61K 47/6901 (2017.08) [A61K 39/39 (2013.01); A61P 35/00 (2018.01); C07K 14/521 (2013.01); C07K 14/77 (2013.01); C07K 16/2851 (2013.01); C12N 7/00 (2013.01); A61K 2039/55572 (2013.01); A61K 2039/585 (2013.01); C07K 2317/622 (2013.01); C07K 2317/77 (2013.01); C07K 2319/33 (2013.01); C07K 2319/42 (2013.01); C07K 2319/735 (2013.01); C07K 2319/74 (2013.01); C12N 2795/14122 (2013.01); C12N 2795/14132 (2013.01); C12N 2795/14145 (2013.01)]

16 Claims

1. A pharmaceutical composition comprising lipid-bacteriophage conjugates, wherein the bacteriophage is conjugated to at least one lipid by means of a non-covalent bond and the bacteriophage lipid ratio is between 3:1 and 100:1; wherein the lipid is selected from the group consisting of alpha-galactosylceramide (aGalCer), glycosphingolipids, palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (PAPC), monophosphoryl lipid A and their natural or synthetic analogues and the bacteriophage is a filamentous bacteriophage.