CPC A61K 47/55 (2017.08) [A61K 47/545 (2017.08); A61P 27/16 (2018.01)] | 7 Claims |
1. A compound having the structure of Formula (1):
X-L-E (1)
wherein X is a cyclin-dependent kinase 2 binding moiety;
L is a linking group selected from:
alkylene, (alkylene oxide)n-alkylene, —C(═O)-alkylene, —C(═O)-alkylene-(alkylene oxide)n-alkylene, —(C═O)-alkylene-O-alkylene, alkylene-(heteroaryl)-(alkylene oxide)m-alkylene-C(═O)—, and alkylene-(heteroaryl)-(alkylene oxide)m-alkylene;
wherein n and m are each independently an integer between 1 and 10; and
E is a ubiquitin ligase binding moiety, wherein X is selected from:
, wherein L is selected from:
wherein n is an integer between 1 and 4, m is an integer between 2 and 4, and p is an integer between 0 and 4
and
, wherein E is selected from:
wherein R8 is selected from:
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