US 11,744,887 B2
Coronavirus vaccine compositions and methods
Sean Michael Sullivan, Escondido, CA (US); Daiki Matsuda, San Diego, CA (US); Kiyoshi Tachikawa, San Diego, CA (US); Padmanabh Chivukula, San Diego, CA (US); Priya Prakash Karmali, San Diego, CA (US); Jared Henry Davis, Poway, CA (US); Yanjie Bao, San Diego, CA (US); and Amit Sagi, San Diego, CA (US)
Assigned to ARCTURUS THERAPEUTICS, INC., San Diego, CA (US)
Filed by Arcturus Therapeutics, Inc., San Diego, CA (US)
Filed on Mar. 9, 2021, as Appl. No. 17/196,889.
Claims priority of provisional application 63/073,900, filed on Sep. 2, 2020.
Claims priority of provisional application 62/987,191, filed on Mar. 9, 2020.
Prior Publication US 2021/0290756 A1, Sep. 23, 2021
Int. Cl. A61K 39/215 (2006.01); C07K 14/005 (2006.01); C12N 15/86 (2006.01); A61K 47/20 (2006.01); A61K 47/26 (2006.01); A61K 47/10 (2017.01); A61K 9/51 (2006.01); A61K 39/12 (2006.01); C07K 14/18 (2006.01); C12N 7/00 (2006.01); A61K 39/00 (2006.01); A61K 38/00 (2006.01)
CPC A61K 39/215 (2013.01) [A61K 9/5123 (2013.01); A61K 39/12 (2013.01); A61K 47/10 (2013.01); A61K 47/20 (2013.01); A61K 47/26 (2013.01); C07K 14/005 (2013.01); C07K 14/1808 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); A61K 2039/53 (2013.01); C12N 2770/20022 (2013.01); C12N 2770/20034 (2013.01); C12N 2770/36122 (2013.01); C12N 2770/36134 (2013.01); C12N 2830/42 (2013.01); C12N 2830/50 (2013.01)] 28 Claims
 
1. A nucleic acid molecule comprising
(a) a sequence of SEQ ID NO:124;
(b) a sequence of SEQ ID NO:124, wherein T is substituted with U;
(c) a sequence of SEQ ID NO:125; or
(d) a sequence of SEQ ID NO:125, wherein T is substituted with U.