CPC A61K 39/0275 (2013.01) [A61K 39/0266 (2013.01); A61K 39/05 (2013.01); A61K 2039/523 (2013.01); A61K 2039/543 (2013.01); A61K 2039/545 (2013.01)] | 20 Claims |
1. An immunogenic live Salmonella Typhi vector that has been engineered to express one or more heterologous antigens from a pathogen, wherein the heterologous antigen comprises outer membrane protein OmpW or an antigenic fragment or variant thereof and comprises outer membrane protein OmpA or an antigenic fragment or variant thereof, wherein the live Salmonella Typhi vector is capable of delivering immunogenic, recombinant outer membrane vesicles (rOMVs) to a mucosal tissue when administered to a subject, wherein the vesicles comprise the heterologous antigens, wherein the Salmonella Typhi vector has been engineered to overexpress a lipid A deacylase PagL.
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