US 11,744,863 B2
Process for preparing a pooled human platelet lysate, pooled human platelet lysate and its use for treating neurological disorders
David Devos, Marcq-en-Baroeul (FR); Thierry Burnouf, Lille (FR); Jean-christophe Devedjian, Lille (FR); Ming-Li Chou, Taoyuan (TW); and Flore Gouel, Ostricourt (FR)
Assigned to Centre Hospitalier Regional et Universitaire De Lille (CHRU), Lille (FR); UNIVERSITE DE LILLE 2 DROIT ET SANTE, Lille (FR); UNIVERSITE DU LITTORAL COTE D'OPALE, Dunkirk (FR); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Paris (FR); and TAIPEI MEDICAL UNIVERSITY, Taipei (TW)
Appl. No. 16/622,446
Filed by CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU), Lille (FR); UNIVERSITE DE LILLE, Lille (FR); UNIVERSITE DU LITTORAL COTE D'OPALE, Dunkirk (FR); INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), Paris (FR); and TAIPEI MEDICAL UNIVERSITY, Taipei (TW)
PCT Filed Jun. 15, 2018, PCT No. PCT/EP2018/066020
§ 371(c)(1), (2) Date Dec. 13, 2019,
PCT Pub. No. WO2018/229278, PCT Pub. Date Dec. 20, 2018.
Claims priority of application No. 17305739 (EP), filed on Jun. 16, 2017.
Prior Publication US 2020/0113942 A1, Apr. 16, 2020
Int. Cl. A61K 35/19 (2015.01); A61P 25/28 (2006.01); A61K 9/00 (2006.01); C12N 5/078 (2010.01)
CPC A61K 35/19 (2013.01) [A61K 9/0085 (2013.01); A61P 25/28 (2018.01); C12N 5/0644 (2013.01)] 13 Claims
 
1. A method for treatment of a neurological disorder, comprising the step of administering a heat-treated pooled human platelet lysate to a patient or subject in need thereof, wherein the heat-treated pooled human platelet lysate has a fibrinogen content of less than 5% by weight of the fibrinogen content of non-heat-treated pHPL and a fibrinogen content of less than 50 ng/mL.