US 11,744,846 B2
Allele specific modulators of P23H rhodopsin
Susan F. Murray, Poway, CA (US); Punit P. Seth, Carlsbad, CA (US); Michael L. McCaleb, La Jolla, CA (US); Susan M. Freier, San Diego, CA (US); and Priyam Singh, San Diego, CA (US)
Filed by Ionis Pharmaceuticals, Inc., Carlsbad, CA (US)
Filed on May 21, 2021, as Appl. No. 17/327,469.
Application 17/327,469 is a continuation of application No. 16/553,799, filed on Aug. 28, 2019, granted, now 11,013,758.
Application 16/553,799 is a continuation of application No. 15/553,876, granted, now 10,426,789, issued on Oct. 1, 2019, previously published as PCT/US2016/019725, filed on Feb. 26, 2016.
Claims priority of provisional application 62/121,286, filed on Feb. 26, 2015.
Prior Publication US 2021/0346421 A1, Nov. 11, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/713 (2006.01); A61P 27/02 (2006.01); C07K 14/705 (2006.01); A61K 31/475 (2006.01); A61K 31/704 (2006.01)
CPC A61K 31/713 (2013.01) [A61K 31/475 (2013.01); A61K 31/704 (2013.01); A61P 27/02 (2018.01); C07K 14/70571 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01); C12N 2310/322 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/3341 (2013.01); C12N 2310/34 (2013.01); C12N 2310/341 (2013.01); C12N 2310/345 (2013.01); C12N 2310/346 (2013.01); C12N 2320/34 (2013.01); C12Q 2600/178 (2013.01)] 14 Claims
 
1. A compound comprising a modified oligonucleotide consisting of 10 to 30 linked nucleosides and having a nucleobase sequence comprising at least 10 contiguous nucleobases of any of the nucleobase sequences of SEQ ID NOs: 11-64.