US 11,744,510 B2
System for imaging lesions aligning tissue surface
Catherine M. Shachaf, Los Gatos, CA (US); and Amit Shachaf, Palo Alto, CA (US)
Assigned to ORLUCENT INC., Los Gatos, CA (US)
Filed by ORLUCENT INC., Los Gatos, CA (US)
Filed on Nov. 9, 2021, as Appl. No. 17/522,279.
Application 17/522,279 is a continuation of application No. 16/184,667, filed on Nov. 8, 2018, granted, now 11,185,278.
Application 16/184,667 is a continuation of application No. 14/364,053, granted, now 10,165,976, issued on Jan. 1, 2019, previously published as PCT/US2012/071246, filed on Dec. 21, 2012.
Claims priority of provisional application 61/578,441, filed on Dec. 21, 2011.
Prior Publication US 2022/0061749 A1, Mar. 3, 2022
Int. Cl. A61B 5/00 (2006.01); G06T 7/73 (2017.01); G06T 7/00 (2017.01); H04N 23/70 (2023.01); H04N 23/67 (2023.01); A61B 1/04 (2006.01)
CPC A61B 5/444 (2013.01) [A61B 5/0071 (2013.01); A61B 5/0077 (2013.01); A61B 5/0082 (2013.01); A61B 5/4887 (2013.01); A61B 5/6833 (2013.01); G06T 7/0012 (2013.01); G06T 7/74 (2017.01); H04N 23/672 (2023.01); H04N 23/673 (2023.01); H04N 23/70 (2023.01); A61B 1/043 (2013.01); A61B 5/0037 (2013.01); A61B 5/443 (2013.01); G06T 2207/10048 (2013.01); G06T 2207/30088 (2013.01); G06T 2207/30096 (2013.01); Y10T 29/49716 (2015.01)] 19 Claims
OG exemplary drawing
 
1. A system comprising (a) an imaging device comprising a fluorescent light filter, wherein the imaging device is configured to image an area of interest comprising a first area and a second area on a surface of an individual, wherein the first area comprises a lesion,
(b) a fluorescent fiducial configured to be applied onto the area of interest;
wherein the fluorescent light filter configured to capture a fluorescent image of the area of interest in a fluorescent mode; and
wherein the imaging device is configured to obtain features of the lesion by combining a visible image and the fluorescent image;
wherein the fluorescent fiducial comprises;
a base that is not visible in a predetermined emission spectra when exposed to light in a predetermined excitation spectra comprising:
a fluorescent calibration mark with a predetermined calibration brightness in the predetermined emission spectra when exposed to light in a predetermined excitation light spectrum,
a fluorescent focus mark with sharply defined borders adapted for use by an autofocus mechanism of an integrated optical system;
a pair of measurement marks with predetermined spacing;
a fluorescent alignment mark visible in both visible light and visible in light in the predetermined emission spectra when exposed to light in the predetermined excitation spectra wherein this mark is not circularly symmetric; and
a direction mark adapted to identify at least one anatomical term of location for the individual.