US 11,733,332 B2
Systems and method of precision functional mapping-guided interventional planning
Chad Sylvester, St. Louis, MO (US); Deanna Greene, St. Louis, MO (US); Scott Marek, St. Louis, MO (US); Scott Norris, St. Louis, MO (US); Jarod Roland, St. Louis, MO (US); Evan Gordon, St. Louis, MO (US); Timothy Laumann, St. Louis, MO (US); Damien Fair, St. Louis, MO (US); Kenneth Bruener, St. Louis, MO (US); and Nico Dosenbach, St. Louis, MO (US)
Assigned to NOUS Imaging, Inc., St. Louis, MO (US)
Filed by NOUS IMAGING, INC., St. Louis, MO (US)
Filed on Dec. 9, 2020, as Appl. No. 17/116,827.
Claims priority of provisional application 62/955,488, filed on Dec. 31, 2019.
Claims priority of provisional application 62/945,524, filed on Dec. 9, 2019.
Prior Publication US 2021/0333343 A1, Oct. 28, 2021
Int. Cl. A61N 1/36 (2006.01); A61B 5/00 (2006.01); A61N 1/372 (2006.01); A61B 5/055 (2006.01); G01R 33/48 (2006.01); G01R 33/563 (2006.01)
CPC A61N 1/36189 (2013.01) [A61B 5/0036 (2018.08); A61B 5/0042 (2013.01); A61B 5/055 (2013.01); A61B 5/7246 (2013.01); A61N 1/3727 (2013.01); G01R 33/4806 (2013.01); G01R 33/56366 (2013.01); A61B 2576/026 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A method of performing functional mapping of a subject for interventional planning, comprising:
using a computer system, acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject;
using a computer system, determining functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data;
identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity;
using a computer system, generating a report indicating the target location; and
wherein determining the functional connectivity of the brain includes determining a temporal correlation of a neurophysiological index.