CPC G01N 33/6857 (2013.01) [G01N 30/7266 (2013.01); G01N 33/6848 (2013.01); H01J 49/0068 (2013.01); H01J 49/045 (2013.01); H01J 49/062 (2013.01); H01J 49/165 (2013.01); H01J 49/168 (2013.01)] | 19 Claims |
1. A method of ionising a sample comprising:
nebulising a sample which includes first biomolecules comprising one or more disulphide (S—S) bonds; and
directing a stream of droplets or charged droplets having one or more disulphide (S—S) bonds so as to pass through an electric field region so as to cause the breaking of a portion of the disulphide bonds, wherein the electric field region is determined by an electrode and an ion inlet of a mass spectrometer, and wherein the electrode is arranged downstream of a nebuliser or electrospray probe.
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