US 11,733,191 B2
Closed-loop controlled chemical apparatus
Arvind Kumar Balijepalli, Washington, DC (US); Curt Andrew Richter, Olney, MD (US); and Son Truong Le, Germantown, MD (US)
Assigned to GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE, Gaithersburg, MD (US)
Filed by Government of the United States of America, as represented by the Secretary of Commerce, Gaithersburg, MD (US)
Filed on Sep. 23, 2020, as Appl. No. 17/29,999.
Claims priority of provisional application 62/904,141, filed on Sep. 23, 2019.
Prior Publication US 2021/0088463 A1, Mar. 25, 2021
Int. Cl. G01N 27/12 (2006.01); G01N 33/483 (2006.01); A61B 5/145 (2006.01); A61K 38/16 (2006.01); A61B 5/00 (2006.01)
CPC G01N 27/12 (2013.01) [A61B 5/14546 (2013.01); A61B 5/4088 (2013.01); A61B 5/4839 (2013.01); A61B 5/7203 (2013.01); A61K 38/16 (2013.01); G01N 33/483 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A closed-loop controlled chemical apparatus comprising:
a compound sensor comprising:
an analyte sensor and that:
produces, by the analyte sensor, a voltage signal that varies in response to an analyte that electrically perturbs the analyte sensor, such that an electrical perturbation changes the voltage signal from a target voltage, the voltage signal referenced to a reference voltage provided by a reference sensor through a composition comprising the analyte;
the reference sensor in electrical communication with the analyte sensor through the composition and that:
receives a feedback control signal from a feedback controller;
actively nulls the difference between the voltage signal and the target voltage when the analyte sensor is perturbed by the analyte to maintain the analyte sensor at the target voltage for suppression of electrical noise fluctuations in the closed-loop controlled chemical apparatus that affect the voltage signal;
a transistor comprising a gate terminal that is in electrical communication with the analyte sensor, such that:
the gate terminal receives a gate potential such that a drain current of the transistor is maintained at a constant value in response to receipt of the feedback control signal by the reference sensor, such that the transistor is operated at an optimal transduction condition comprising peak sensitivity of the transistor and minimum noise of the transistor based on the feedback control signal;
the feedback controller in electrical communication with the transistor and that:
receives a transduction signal;
determines a deviation of the transduction signal from a setpoint, the setpoint determined by transfer characteristics of the transistor;
produces the feedback control signal that minimizes the deviation of the transduction signal from the setpoint based on a control model; and
communicates the feedback control signal to the reference sensor for suppression of electrical noise fluctuations in the closed-loop controlled chemical apparatus.