US 11,733,150 B2
Distinguishing between blood sample components
Yochay Shlomo Eshel, Sde Warburg (IL); Arnon Houri Yafin, Jerusalem (IL); Joseph Joel Pollak, Neve Daniel (IL); Neta Bachar, Netanya (IL); Annael Marciano, Jerusalem (IL); and Sarah Levy Schreier, Tel Aviv (IL)
Assigned to S.D. Sight Diagnostics Ltd., Tel Aviv (IL)
Appl. No. 16/88,321
Filed by S.D. Sight Diagnostics Ltd., Tel Aviv (IL)
PCT Filed Mar. 23, 2017, PCT No. PCT/IL2017/050363
§ 371(c)(1), (2) Date Sep. 25, 2018,
PCT Pub. No. WO2017/168411, PCT Pub. Date Oct. 5, 2017.
Claims priority of provisional application 62/315,223, filed on Mar. 30, 2016.
Prior Publication US 2020/0300750 A1, Sep. 24, 2020
Int. Cl. G01N 15/14 (2006.01); G01N 33/49 (2006.01); G06V 20/69 (2022.01); G01N 1/30 (2006.01); G02B 21/36 (2006.01); G01N 15/10 (2006.01)
CPC G01N 15/1475 (2013.01) [G01N 1/30 (2013.01); G01N 33/49 (2013.01); G02B 21/367 (2013.01); G01N 2015/1006 (2013.01); G06V 20/698 (2022.01)] 28 Claims
OG exemplary drawing
 
1. Apparatus for use with a blood sample that was drawn from a subject and an output device, the apparatus comprising:
a microscope system configured to acquire:
a first image of the blood sample, using a microscope system, and
a second image of the blood sample, there being a time interval between acquisitions of the first and second images; and
a computer processor configured to:
analyze the first image of the blood sample, and
only in response to determining by the analysis of the first image that there are one or more entities within the image that may be either an extra-erythrocytic entity or an intra-erythrocytic entity:
select to compare the first and second images of the blood sample to one another,
compare the first and second images of the blood sample to one another, and
determine a characteristic of the blood sample, at least partially based upon comparing the first and second images of the blood sample to one another by:
determining whether between acquisitions of the first and second images, there was relative motion between at least one erythrocyte within the sample and at least one entity within the sample; and
at least partially in response thereto, determining whether the entity is an extra-erythrocytic or an intra-erythrocytic entity, and generate an output in response to the determined characteristic.