CPC C12N 15/1058 (2013.01) [A61K 39/21 (2013.01); C07K 16/1063 (2013.01); C07K 19/00 (2013.01); C12N 15/1062 (2013.01); G01N 33/6845 (2013.01); A61K 2039/575 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2319/91 (2013.01); C12N 2740/16122 (2013.01); C12N 2740/16134 (2013.01); G01N 2405/00 (2013.01)] | 9 Claims |
1. A method of inducing an immune response in an individual comprising:
administering to an individual: (i) a glycopolypeptide comprising one or more modified amino acid residues having a sidechain comprising a monosaccharide or an oligosaccharide, wherein the glycopolypeptide binds specifically to a carbohydrate-binding monoclonal antibody with an affinity of less than 100 nM; (ii) an immunogenic conjugate comprising said glycopolypeptide covalently or non-covalently bound to an immunogenic carrier molecule; or (iii) a pharmaceutical composition comprising a pharmaceutically acceptable carrier and said glycopolypeptide or said immunogenic conjugate,
wherein said administering is effective to induce an immune response against the glycopolypeptide, and
wherein the glycopolypeptide comprises (a) the amino acid sequence of XxSIPxYTY (SEQ ID NO: 2) where each x at positions 2 and 6 is optional and can be any amino acid and X at position 1 is one of said one or more modified amino acid residues, or (b) one of the following amino acid sequences:
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where X is one of said one or more modified amino acid residues.
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