US 11,732,238 B2
Main-chain liquid crystalline hydrogels for cell culture
Kelly Anne Burke, Sutton, MA (US); and Yongjian Wang, Monroe, NJ (US)
Assigned to University of Connecticut, Farmington, CT (US)
Filed by University of Connecticut, Farmington, CT (US)
Filed on May 4, 2021, as Appl. No. 17/307,808.
Claims priority of provisional application 63/033,575, filed on Jun. 2, 2020.
Claims priority of provisional application 63/019,943, filed on May 4, 2020.
Prior Publication US 2021/0348122 A1, Nov. 11, 2021
Int. Cl. C12N 5/00 (2006.01); C12N 5/0775 (2010.01); C09K 19/34 (2006.01)
CPC C12N 5/0068 (2013.01) [C09K 19/348 (2013.01); C12N 5/0662 (2013.01); C12N 2513/00 (2013.01); C12N 2533/30 (2013.01); C12N 2537/10 (2013.01); C12N 2539/00 (2013.01)] 20 Claims
 
1. A polymer of formula (I),

OG Complex Work Unit Chemistry
wherein
A1, A2, A3, and A4 are each independently a phenyl optionally substituted with 1, 2, 3, or 4 Ra;
L1, L2, X1, and X2 are each independently O, NH, C(O), C(O)O, C(O)NH, or OC(O)NH;
T1 and T2 are each independently C1-6alkylene;
W is W0-L; wherein W0 is selected from the group consisting of a polyether, a polyester, a polyamide, a polysiloxane, a polyurethane, and a combination thereof; and wherein L is a bond or —S—S—;
Ra at each occurrence is independently —NH2, —OH, —COOH, —CHO, halogen, cyano, —Oalkyl, —NHalkyl, —N(alkyl)2, —C(O)alkyl, —C(O)Oalkyl, —OC(O)alkyl, —C(O)NHalkyl, —NHC(O)alkyl, or an alkyl optionally substituted with —NH2, —OH, —COOH, or —CHO; and
x is 1 to 100.