US 11,732,060 B2
Crosslinked polymeric network and use thereof
George L. Grobe, III, Ontario, NY (US); Alok Kumar Awasthi, Pittsford, NY (US); Mark R. Mis, Rush, NY (US); Jennah L. Wolcott, Perry, NY (US); and James R. Hauenstein, Williamson, NY (US)
Assigned to BAUSCH & LOMB INCORPORATED, Rochester, NY (US)
Filed by Bausch & Lomb Incorporated, Rochester, NY (US)
Filed on Jan. 10, 2020, as Appl. No. 16/739,547.
Claims priority of provisional application 62/798,668, filed on Jan. 30, 2019.
Prior Publication US 2020/0239601 A1, Jul. 30, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. C08B 37/00 (2006.01); A61K 9/00 (2006.01); A61K 31/726 (2006.01); A61K 31/728 (2006.01); C08B 37/08 (2006.01); G02C 7/04 (2006.01); A45C 11/00 (2006.01); A61L 26/00 (2006.01); A61L 27/34 (2006.01)
CPC C08B 37/0069 (2013.01) [A45C 11/005 (2013.01); A61K 9/0048 (2013.01); A61K 31/726 (2013.01); A61K 31/728 (2013.01); A61L 26/0023 (2013.01); A61L 27/34 (2013.01); C08B 37/0072 (2013.01); G02C 7/049 (2013.01)] 48 Claims
 
1. A crosslinked polymeric network comprising (a) a reaction product of a first glycosaminoglycan, a second glycosaminoglycan, and a first crosslinking agent, wherein the first glycosaminoglycan is hyaluronic acid or a salt thereof having a weight average molecular weight ranging from about 10,000 to about 200,000, the second glycosaminoglycan is chondroitin sulfate having a weight average molecular weight ranging from about 10,000 to about 100,000; and (b) one or more third glycosaminoglycans crosslinked with the reaction product with a second crosslinking agent.