US 11,732,029 B2
Methods and compositions for the treatment of wounds
Jeffrey A. Hubbell, Chicago, IL (US); Anna M. Randi, London (GB); Jun Ishihara, Chicago, IL (US); Ako Ishihara, Chicago, IL (US); Priscilla Briquez, Chicago, IL (US); and Richard Starke, London (GB)
Assigned to The University Chicago, Chicago, IL (US); and Imperial College Innovations Limited, London (GB)
Appl. No. 15/733,085
Filed by The University of Chicago, Chicago, IL (US); and Imperial College Innovations Limited, London (GB)
PCT Filed Nov. 13, 2018, PCT No. PCT/US2018/060760
§ 371(c)(1), (2) Date May 13, 2020,
PCT Pub. No. WO2019/094938, PCT Pub. Date May 16, 2019.
Claims priority of provisional application 62/585,101, filed on Nov. 13, 2017.
Claims priority of provisional application 62/758,845, filed on Nov. 12, 2018.
Prior Publication US 2021/0040179 A1, Feb. 11, 2021
Int. Cl. A61K 38/00 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); C07K 14/00 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); C07K 14/475 (2006.01); A61P 17/02 (2006.01); A61K 38/16 (2006.01); C07K 14/78 (2006.01); A61L 27/22 (2006.01); C07K 16/18 (2006.01); A61K 9/00 (2006.01); A61K 9/70 (2006.01); C07K 14/705 (2006.01); A61K 47/64 (2017.01); C07K 14/81 (2006.01); A61K 47/69 (2017.01); A61K 38/39 (2006.01)
CPC C07K 14/78 (2013.01) [A61K 9/0024 (2013.01); A61K 9/7007 (2013.01); A61K 38/00 (2013.01); A61K 38/18 (2013.01); A61K 38/39 (2013.01); A61K 47/6435 (2017.08); A61K 47/6903 (2017.08); A61L 27/22 (2013.01); A61P 17/02 (2018.01); C07K 14/475 (2013.01); C07K 14/70546 (2013.01); C07K 14/8121 (2013.01); C07K 16/18 (2013.01); A61L 2300/412 (2013.01); C07K 2317/55 (2013.01); C07K 2319/70 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A polypeptide comprising a growth factor binding domain comprising 25-100 contiguous amino acids of SEQ ID NO: 13 and wherein the 25-100 contiguous amino acids include SEQ ID NO: 1, and wherein the polypeptide is attached to a transglutaminase-reactive peptide having the amino acid sequence of SEQ ID NO:12.