CPC C07D 487/04 (2013.01) [A61K 9/0014 (2013.01); C07D 519/00 (2013.01)] | 17 Claims |
1. A compound of formula (I):
or a pharmaceutically acceptable salt or stereoisomer thereof,
wherein:
A represents N;
R1 represents NH2;
R2 represents F, Cl, Br, I, or NH2;
R3 represents a fused, bicyclic heteroaryl, wherein the fused, bicyclic heteroaryl is optionally substituted with one or more substituents independently selected from the group consisting of F, Cl, Br, I, CN, CH3, CH2CH3, CF3, NHR5, and OR6;
R4 represents C3-C10 alkyl or C3-C10 carbocyclyl;
wherein the C3-C10 alkyl is branched;
wherein the C3-C10 carbocyclyl is optionally bicyclic;
wherein the C3-C10 alkyl or C3-C10 carbocyclyl is optionally interrupted with one heteroatom selected from the group consisting of O and S; and
wherein the C3-C10 alkyl or C3-C10 carbocyclyl is optionally substituted with one or more substituents independently selected from the group consisting of F, C3-C6 cycloalkyl, and heterocycloalkyl;
R5 represents H, C1-C6 alkyl, acyl, or cyclopropyl;
wherein the C1-C6 alkyl is saturated or unsaturated;
wherein the C1-C6 alkyl is optionally interrupted with one heteroatom selected from the group consisting of O and S; and
wherein the C1-C6 alkyl is optionally substituted with one substituent selected from the group consisting of C3-C5 cycloalkyl and heterocycloalkyl; and
R6 represents H or CH3.
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6. A pharmaceutical composition comprising a compound according to claim 1, or a pharmaceutically acceptable salt or stereoisomer thereof, in a physiologically acceptable medium.
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