CPC C07D 413/14 (2013.01) | 18 Claims |
1. A process for the preparation of Formula 15:
wherein X is halogen, —OTf, —OTs, or —OMs; and
each PG is methyl, benzyl, p-methoxybenzyl, methoxymethyl, [2-(trimethylsilyl)ethoxylmethyl, triisopropylsilyl, or tert-butyldimethylsilyl; comprising:
(1) contacting the compound of Formula 14:
wherein X is halogen, —OTf, —OTs, or —OMs; and
each PG is methyl, benzyl, p-methoxybenzyl, methoxymethyl, [2-(trimethylsilyl)ethoxylmethyl, triisopropylsilyl, or tert-butyldimethylsilyl;
with a suitable oxidation reagent system in a suitable solvent to provide a compound of Formula 15;
wherein:
the suitable oxidation reagent system of step (1) is Collins reagent, pyridinium dichromate, pyridinium chlorochromate, Dess-Martin periodinane, 2-iodobenzoic acid, a TPAP/NMO system, or a TEMPO/bleach system; and
the suitable solvent of step (1) is acetonitrile, dimethylsulfoxide, dichloromethane, chloroform, dichloroethane, hexanes, ethyl acetate, acetic acid, toluene, water, or a combination thereof.
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