CPC C07D 317/70 (2013.01) [A61P 35/00 (2018.01); C07C 39/38 (2013.01); C07C 43/225 (2013.01); C07C 49/255 (2013.01); C07C 59/72 (2013.01); C07C 61/29 (2013.01); C07C 62/32 (2013.01); C07C 65/11 (2013.01); C07C 69/708 (2013.01); C07C 69/712 (2013.01); C07C 69/757 (2013.01); C07C 233/02 (2013.01); C07C 233/58 (2013.01); C07C 235/34 (2013.01); C07C 235/40 (2013.01); C07D 263/52 (2013.01); C07D 317/52 (2013.01); C07D 319/14 (2013.01); C07C 2601/14 (2017.05); C07C 2602/08 (2017.05)] | 15 Claims |
1. A compound of formula (I):
wherein:
one of R1 or R2 is hydroxyl, and the other is hydroxyl, alkyl, alkoxy, methoxy-acetate, phosphate, valine, Gly-Ser, —OC(O)CH2OC(O)CH3, —OC(O)CH2OCH3, —OCH2C(O)C(CH3)3, —OCH2C(O)NH2 or —OCH2C(O)OH; or R1 and R2, together with the carbon atoms to which they are attached, form a 5 to 6-membered ring with one or two ring carbons replaced independently by oxygen or nitrogen;
R3 is —CF3; and
R4 is alkenyl, said alkenyl optionally mono or bi-substituted independently with hydrogen, halogen, hydroxyl, —OCH2-phenyl, cycloalkyl, —OCH2-halophenyl or —OCH2-phenylhaloalkyl,
or a pharmaceutically acceptable salt thereof.
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