US 11,731,935 B2
Prodrugs of fencamfamine
Sandeep Patil, Menlo Park, CA (US); Ron Bihovsky, Wynnewood, PA (US); Steven A Smith, San Jose, CA (US); Yuhua Ji, Palo Alto, CA (US); Valentino Stella, Lawrence, KS (US); Daniel D. Long, San Francisco, CA (US); and Daniel Marquess, Half Moon Bay, CA (US)
Assigned to Praxis Bioresearch, LLC, Menlo Park, CA (US)
Filed by PRAXIS BIORESEARCH, LLC, Menlo Park, CA (US)
Filed on Apr. 14, 2020, as Appl. No. 16/847,988.
Application 16/847,988 is a continuation of application No. 15/758,466, granted, now 10,662,146, previously published as PCT/US2016/051534, filed on Sep. 13, 2016.
Claims priority of provisional application 62/308,078, filed on Mar. 14, 2016.
Claims priority of provisional application 62/298,267, filed on Feb. 22, 2016.
Claims priority of provisional application 62/219,052, filed on Sep. 15, 2015.
Prior Publication US 2020/0399203 A1, Dec. 24, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. C07C 271/24 (2006.01); A61K 9/00 (2006.01); A61K 47/10 (2017.01); A61K 47/26 (2006.01); A61K 47/64 (2017.01); A61K 47/38 (2006.01); C07C 237/04 (2006.01); C07K 5/062 (2006.01); C07C 237/22 (2006.01); C07C 233/06 (2006.01); C07C 271/56 (2006.01); A61K 47/54 (2017.01); C07C 237/20 (2006.01)
CPC C07C 237/04 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 9/0095 (2013.01); A61K 47/10 (2013.01); A61K 47/26 (2013.01); A61K 47/38 (2013.01); A61K 47/542 (2017.08); A61K 47/64 (2017.08); C07C 233/06 (2013.01); C07C 237/20 (2013.01); C07C 237/22 (2013.01); C07C 271/24 (2013.01); C07C 271/56 (2013.01); C07K 5/06026 (2013.01); C07K 5/06052 (2013.01); C07B 2200/07 (2013.01); C07C 2602/42 (2017.05)] 15 Claims
 
1. A prodrug composition comprising at least one conjugate of N-ethyl-3-phenylbicyclo[2.2.1]heptan-2-amine or any of its stereoisomers, wherein the conjugate is a compound selected from the group consisting of:

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry