	US 11,731,927 B2
	Cocrystals of ubiquinol and compositions comprising them
Rafel Prohens López, Sabadell (ES); Rafael Barbas Cañero, Santa Coloma de Gramenet (ES); Lidia Bofill Herrera, Bigues i Riells (ES); and Dafne De Sande López, L'Hospitalet de Llobregat (ES)
Assigned to CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L., Palma de Mallorca (ES)
Appl. No. 16/969,869
Filed by Center for Intelligent Research in Crystal Engineering, S.L., Palma de Mallorca (ES)
PCT Filed Feb. 22, 2019, PCT No. PCT/EP2019/054420 § 371(c)(1), (2) Date Aug. 13, 2020, PCT Pub. No. WO2019/162429, PCT Pub. Date Aug. 29, 2019.
Claims priority of application No. 18382109 (EP), filed on Feb. 23, 2018.
Prior Publication US 2020/0385327 A1, Dec. 10, 2020
Int. Cl. C07C 43/23 (2006.01); C07C 65/05 (2006.01); A61K 45/06 (2006.01)

CPC C07C 43/23 (2013.01) [C07C 65/05 (2013.01); A61K 45/06 (2013.01); C07B 2200/13 (2013.01)]

16 Claims

1. A cocrystal of ubiquinol and a hydrogen bond donor coformer,

wherein the hydrogen bond donor coformer is selected from the group consisting of 3-hydroxybenzoic acid and 3,4-dihydroxybenzoic acid,

wherein in the cocrystal of ubiquinol and 3-hydroxybenzoic acid, the molar ratio of ubiquinol and 3-hydroxybenzoic acid is 1:1;

wherein the cocrystal of ubiquinol and 3,4-dihydroxybenzoic acid is a hydrate; and

wherein in the cocrystal of ubiquinol and 3,4-dihydroxybenzoic acid, the molar ratio of ubiquinol, 3,4-dihydroxybenzoic acid, and water is 1:1:1.