US 11,731,132 B2
Methods and devices for detection of multiple analytes from a biological sample
Rajaram Krishnan, San Diego, CA (US); Juan Pablo Hinestrosa Salazar, San Diego, CA (US); Robert Paul Turner, San Diego, CA (US); David Joseph Searson, San Diego, CA (US); James Gregory Madsen, San Diego, CA (US); and Robert Kovelman, La Jolla, CA (US)
Assigned to BIOLOGICAL DYNAMICS, INC., San Diego, CA (US)
Appl. No. 16/955,707
Filed by Biological Dynamics, Inc., San Diego, CA (US)
PCT Filed Dec. 19, 2018, PCT No. PCT/US2018/066602
§ 371(c)(1), (2) Date Jun. 18, 2020,
PCT Pub. No. WO2019/126388, PCT Pub. Date Jun. 27, 2019.
Claims priority of provisional application 62/607,873, filed on Dec. 19, 2017.
Prior Publication US 2021/0101150 A1, Apr. 8, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. B01L 3/00 (2006.01); C12Q 1/6806 (2018.01); G01N 21/64 (2006.01)
CPC B01L 3/502761 (2013.01) [C12Q 1/6806 (2013.01); B01L 2300/0636 (2013.01); B01L 2300/0645 (2013.01); B01L 2400/0424 (2013.01); G01N 2021/6439 (2013.01); G01N 2800/26 (2013.01); G01N 2800/7028 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for analyzing a biological sample comprising:
capturing a plurality of analytes in the biological sample using an electrode configured to generate an AC dielectrophoretic field, wherein the plurality of analytes comprises at least two types of analytes selected from the group consisting of DNA, RNA, nucleosomes, exosomes, extracellular vesicles, proteins, cell membrane fragments, mitochondria and cellular vesicles; and
detecting the plurality of analytes, wherein detecting the plurality of analytes comprises detecting at least two different species of DNA, RNA, nucleosomes, exosomes, extracellular vesicles, proteins, cell membrane fragments, mitochondria or cellular vesicles.