US 11,730,952 B2
Apparatus and method for decoding and restoring cognitive functions
Dong Song, Walnut, CA (US); and Theodore William Berger, Rancho Palos Verdes, CA (US)
Assigned to University of Southern California, Los Angeles, CA (US)
Appl. No. 16/639,556
Filed by University of Southern California, Los Angeles, CA (US)
PCT Filed Aug. 16, 2018, PCT No. PCT/US2018/000151
§ 371(c)(1), (2) Date Feb. 14, 2020,
PCT Pub. No. WO2019/035887, PCT Pub. Date Feb. 21, 2019.
Claims priority of provisional application 62/546,468, filed on Aug. 16, 2017.
Claims priority of provisional application 62/546,494, filed on Aug. 16, 2017.
Prior Publication US 2020/0238074 A1, Jul. 30, 2020
Int. Cl. A61B 5/00 (2006.01); A61N 1/36 (2006.01); A61B 5/291 (2021.01); A61N 1/05 (2006.01)
CPC A61N 1/0531 (2013.01) [A61B 5/291 (2021.01); A61B 5/4094 (2013.01); A61B 5/686 (2013.01); A61B 5/6868 (2013.01); A61B 5/7264 (2013.01); A61N 1/36082 (2013.01); A61N 1/36103 (2013.01); A61N 1/36139 (2013.01); A61N 1/36178 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A hippocampal prosthesis for bypassing a damaged portion of a subject's hippocampus and restoring the subject's ability to form long-term memories, comprising:
a first set of hippocampal electrodes configured to receive an input signal from at least one of the subject's hippocampus or surrounding cortical region;
a processing device having:
a memory, and
one or more processors operatively coupled to the memory and to the first set of hippocampal electrodes and configured to generate an output signal based on the input signal received from the first set of hippocampal electrodes; and
a second set of hippocampal electrodes operatively coupled to the one or more processors and configured to receive and transmit the output signal to the subject's hippocampus;
wherein the output signal is based on a multiple-input multiple-output (MIMO) model of spike train transformation, and wherein the one or more processors are further configured to optimize the MIMO model with a sparse representation of model coefficients.