	US 11,730,865 B2
	Embolic compositions and methods
Amarpreet S. Sawhney, Lexington, MA (US); Hans Claesson, Lexington, MA (US); Raymond Lareau, Westford, MA (US); and Douglas Billings, Wellesley, MA (US)
Assigned to Incept, LLC, Lexington, MA (US)
Filed by Incept, LLC, Lexington, MA (US)
Filed on May 10, 2019, as Appl. No. 16/409,633.
Claims priority of provisional application 62/671,836, filed on May 15, 2018.
Prior Publication US 2019/0351107 A1, Nov. 21, 2019
Int. Cl. A61L 31/04 (2006.01); A61M 25/00 (2006.01); A61L 31/14 (2006.01); A61B 17/12 (2006.01); A61L 24/00 (2006.01); A61L 24/02 (2006.01); A61L 24/06 (2006.01); C08F 120/28 (2006.01); C08F 4/38 (2006.01)

CPC A61L 31/048 (2013.01) [A61B 17/12113 (2013.01); A61B 17/12186 (2013.01); A61B 17/12195 (2013.01); A61L 24/0031 (2013.01); A61L 24/02 (2013.01); A61L 24/06 (2013.01); A61L 31/145 (2013.01); A61M 25/0026 (2013.01); C08F 120/28 (2013.01); A61L 2300/44 (2013.01); A61L 2300/80 (2013.01); A61L 2400/06 (2013.01); A61L 2430/36 (2013.01); A61M 2025/0039 (2013.01); C08F 4/38 (2013.01)]

17 Claims

1. A method of embolization comprising

delivering a first liquid comprising an initiator through a first catheter lumen to a target lumen and delivering a second liquid that comprises a co-initiator through a second catheter lumen to the target lumen, with at least one of the first liquid and the second liquid comprising a water soluble polymer that comprises at least 80% by weight, based on the total weight of the water soluble polymer, of polyethylene glycol having a plurality of functional groups that form radical initiated crosslinks,

wherein the initiator and the co-initiator react with each other to form a radical initiator that initiates a free radical polymerization of the water soluble polymer functional groups to crosslink the water soluble polymer to form an embolization material in the target lumen when the first liquid and the second liquid mix with each other wherein the crosslinked polymer is a hydrogel with a swelling of about 20% or greater.