US 11,730,852 B2
Antimicrobial or wound care materials, devices and uses
Amy Brewster, Hull (GB); Robert Crump, Nettleton (GB); Helene Anne Lecomte, York (GB); David Stephenson, Hull (GB); and Matthew Wray, Hessle (GB)
Assigned to Smith & Nephew PLC, Watford (GB)
Appl. No. 16/630,387
Filed by Smith & Nephew PLC, Watford (GB)
PCT Filed Jul. 12, 2018, PCT No. PCT/EP2018/069015
§ 371(c)(1), (2) Date Jan. 10, 2020,
PCT Pub. No. WO2019/012069, PCT Pub. Date Jan. 17, 2019.
Claims priority of application No. 1711183 (GB), filed on Jul. 12, 2017.
Prior Publication US 2021/0085819 A1, Mar. 25, 2021
Int. Cl. A61L 15/20 (2006.01); A61L 15/42 (2006.01); A61L 15/60 (2006.01)
CPC A61L 15/20 (2013.01) [A61L 15/425 (2013.01); A61L 15/60 (2013.01); A61L 2300/104 (2013.01); A61L 2300/404 (2013.01)] 20 Claims
 
1. Material which is a wound care material comprising:
a flexible hydrophilic polymer foam or fibre matrix comprising a wound facing face and a reverse face or two wound facing faces and therebetween a structural matrix framework defining a network of cells having a cell network surface and therein a network of pores or cell openings, and
a powder charge comprising a wound dressing additive or combinations thereof,
wherein said matrix provides a tortuous pore network;
wherein said powder charge is comprised at said wound facing face or said reverse face and within said cell network, wherein said powder charge is within said cell network in diminishing amount with increasing depth within said network; wherein more than 50% of the powder charge is present within 0.8 mm from a surface of the foam or fibre matrix; and
wherein the powder charge further comprises a flowing agent selected from a group consisting of clay, silica, charcoal, graphite and a combination thereof;
wherein the flowing agent has a particle size distribution D50<10 micron.
 
6. A method of treating a wound, comprising:
placing a wound dressing comprising a loaded wound dressing layer into or over the wound, wherein the loaded wound dressing layer comprises a porous matrix and a powder charge of antimicrobial release additive loaded within the matrix, wherein the powder charge is concentrated at least at a wound facing surface of the porous matrix and more than 50% of the powder charge is present within 0.8 mm from a surface of the wound facing surface;
wherein the antimicrobial release additive is activated for the release of an antimicrobial agent into the wound from the wound dressing upon contact with moist or aqueous medium; and
wherein the powder charge further comprises a flowing agent selected from a group consisting of clay, silica, charcoal, graphite and a combination thereof;
wherein the flowing agent has a particle size distribution D50<10 micron.
 
7. A wound dressing, comprising:
a loaded wound dressing layer comprising:
a porous matrix comprising a wound facing face and a reverse face; and
a powder charge of antimicrobial release additive loaded within the matrix, wherein the powder charge decreases in amount with increasing distance from at least the wound facing face and more than 50% of the powder charge is present within 0.8 mm from a surface of the wound facing face;
wherein the powder charge further comprises a flowing agent selected from a group consisting of clay, silica, charcoal, graphite and a combination thereof;
wherein the flowing agent has a particle size distribution D50<10 micron.