US 11,730,833 B2
Coated plant virus imaging agents
Nicole F. Steinmetz, San Diego, CA (US); Michael Bruckman, Cleveland, OH (US); and Lauren Randolph, State College, PA (US)
Assigned to CASE WESTERN UNIVERSITY, Cleveland, OH (US)
Filed by CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed on Nov. 9, 2021, as Appl. No. 17/522,182.
Application 17/522,182 is a continuation of application No. 16/279,482, filed on Feb. 19, 2019, granted, now 11,167,047, issued on Nov. 9, 2021.
Application 16/279,482 is a continuation of application No. 15/937,681, filed on Mar. 27, 2018, granted, now 10,207,014, issued on Feb. 19, 2019.
Application 15/937,681 is a continuation of application No. 14/818,812, filed on Aug. 5, 2015, granted, now 9,925,281, issued on Mar. 27, 2018.
Claims priority of provisional application 62/033,297, filed on Aug. 5, 2014.
Prior Publication US 2022/0211881 A1, Jul. 7, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 49/18 (2006.01); A61K 49/10 (2006.01); A61K 49/08 (2006.01)
CPC A61K 49/1896 (2013.01) [A61K 49/085 (2013.01); A61K 49/108 (2013.01)] 13 Claims
 
1. An imaging nanoparticle, comprising a tobacco mosaic virus particle having an interior surface and an exterior surface, a chelated lanthanide imaging agent that is linked to the exterior surface, and a layer of silica coated over the exterior surface, wherein the tobacco mosaic virus particle is selected from the group consisting of iGd-TMV-Si, eGd-TMV, eGd-TMV-Si, Gd-SNP, and Gd-SNP-Si, and wherein the tobacco mosaic virus particle has a relaxivity of greater than about 25,000 mM−1S−1 per particle.