CPC A61K 49/1896 (2013.01) [A61K 49/085 (2013.01); A61K 49/108 (2013.01)] | 13 Claims |
1. An imaging nanoparticle, comprising a tobacco mosaic virus particle having an interior surface and an exterior surface, a chelated lanthanide imaging agent that is linked to the exterior surface, and a layer of silica coated over the exterior surface, wherein the tobacco mosaic virus particle is selected from the group consisting of iGd-TMV-Si, eGd-TMV, eGd-TMV-Si, Gd-SNP, and Gd-SNP-Si, and wherein the tobacco mosaic virus particle has a relaxivity of greater than about 25,000 mM−1S−1 per particle.
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