CPC A61K 47/64 (2017.08) [A61K 47/65 (2017.08); C07K 7/54 (2013.01)] | 23 Claims |
1. A compound comprising a looped peptide structure attached via at least one alkylamino linkage to a molecular scaffold, wherein the looped peptide structure is a Bicycle structure comprising two peptide loops subtended between three linkages to the scaffold, a central linkage attached to the two peptide loops, wherein the molecular scaffold comprises a tris-substituted (hetero)aromatic or (hetero)alicyclic moiety, and wherein the looped peptide structure comprises a sequence:
(X)lA1(X)mA2(X)nA3(X)o;
or a pharmaceutically acceptable salt thereof,
wherein:
A1, A2 and A3 are selected from cysteine, Dap, N-AlkDap, or N-HAlkDap, provided that at least one of A1, A2 and A3 is Dap, N-AlkDap or N-HAlkDap, wherein each of A1, A2 and A3 attaches to the molecular scaffold via a thioether linkage or an alkylamino linkage;
X is any amino acid residue;
m is 3, 4, 5, 6, 7, 8 or 9;
n is 3, 4, 5, 6, 7, 8 or 9;
l is a number between 0 and 20; and
o is a number between 0 and 20.
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