CPC A61K 47/549 (2017.08) [A61K 31/7084 (2013.01); A61K 45/06 (2013.01); A61K 47/643 (2017.08); A61K 47/65 (2017.08); A61K 47/6807 (2017.08); A61K 47/6849 (2017.08); A61K 47/6889 (2017.08)] | 25 Claims |
1. A Pro-CDN compound of Formula (Ib):
or pharmaceutically acceptable salts, stereoisomers, tautomers or solvates thereof;
wherein:
the CDN unit is a cyclic dinucleotide monophosphorothioate or diphosphorothioate of Formula (IIa):
wherein:
X1 and Y1 are independently H or F;
X2 and Y2 are independently H or F;
Z1 is O or S;
R1 is H when Z1 is O;
R1 is H or a linker system when Z1 is S;
B1 and B2 are purine bases chosen from:
the specifier is a peptide sequence which can be cleaved by a specific protease; and
W1 is an amide, an ester, a urea, a disulfide bridge, a carbamate, a hydrazone, an imine, an oxime, or a triazole group.
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