CPC A61K 39/39591 (2013.01) [A61K 9/0019 (2013.01); A61K 9/19 (2013.01); A61K 47/183 (2013.01); A61K 47/26 (2013.01); C07K 16/244 (2013.01); A61K 47/14 (2013.01); A61K 47/34 (2013.01); C07K 2317/565 (2013.01)] | 40 Claims |
1. An antibody formulation comprising:
(a) an anti-Interleukin-36 receptor (anti-IL-36R) antibody or an antigen binding fragment thereof present at a concentration within the range from about 10 mg/mL to about 200 mg/mL;
(b) an acetate buffer present at a concentration of about 45 mM;
(c) sucrose present at a concentration of about 150 mM;
(d) L-arginine or a pharmaceutically acceptable salt thereof present at a concentration of about 25 mM; and
(e) polysorbate 20 present at a concentration of about 0.4 g/L;
wherein the formulation in liquid form or when reconstituted with water is characterized by a pH within the range from about 5 to about 6; and
further wherein the anti-IL-36R antibody or an antigen binding fragment thereof is selected from the following:
(i) an antibody or an antigen binding fragment thereof comprising a light chain variable region comprising the amino acid sequence of SEQ ID NO: 80; and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 87; or
(ii) an antibody or an antigen binding fragment thereof the amino acid sequence of SEQ ID NO: 80; and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 88; or
(iii) an antibody or an antigen binding fragment thereof the amino acid sequence of SEQ ID NO: 80; and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 89.
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