US 11,730,801 B2
Live attenuated Zika virus with 3'UTR deletion, vaccine containing and use thereof
Pei-Yong Shi, Galveston, TX (US); Xuping Xie, Galveston, TX (US); and Chao Shan, Galveston, TX (US)
Assigned to Board of Regents, The University of Texas System, Austin, TX (US)
Appl. No. 16/485,818
Filed by THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
PCT Filed Feb. 14, 2018, PCT No. PCT/US2018/018114
§ 371(c)(1), (2) Date Aug. 14, 2019,
PCT Pub. No. WO2018/152158, PCT Pub. Date Aug. 23, 2018.
Claims priority of provisional application 62/458,839, filed on Feb. 14, 2017.
Prior Publication US 2020/0197505 A1, Jun. 25, 2020
Int. Cl. A61K 39/00 (2006.01); A61K 39/12 (2006.01); A61P 31/14 (2006.01)
CPC A61K 39/12 (2013.01) [A61P 31/14 (2018.01); A61K 2039/53 (2013.01); A61K 2039/555 (2013.01); A61K 2039/57 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A live attenuated Zika virus (ZIKV) strain, comprising a deletion in the 3′ untranslated region (3′UTR) of the ZIKV viral genome, the deletion comprising a deletion of sequence CCAGAAGAGG (SEQ ID NO:8).