	US 11,730,758 B2
	Compositions and methods comprising energy absorbing materials for follicular delivery
Dilip Paithankar, Wayland, MA (US); Richard Dean Blomgren, Dacula, GA (US); Richard Rox Anderson, Boston, MA (US); William A. Farinelli, Danvers, MA (US); and Apostolos G. Doukas, Cambridge, MA (US)
Assigned to The General Hospital Corporation, Boston, MA (US)
Filed by The General Hospital Corporation, Boston, MA (US)
Filed on May 18, 2020, as Appl. No. 16/876,835.
Application 16/876,835 is a continuation of application No. 16/596,309, filed on Oct. 8, 2019, abandoned.
Application 16/596,309 is a continuation of application No. 15/861,343, filed on Jan. 3, 2018, abandoned.
Application 16/596,309 is a continuation of application No. 15/459,184, filed on Mar. 15, 2017, abandoned.
Application 15/861,343 is a continuation of application No. 14/951,444, filed on Nov. 24, 2015, abandoned.
Application 15/459,184 is a continuation of application No. 13/828,429, filed on Mar. 14, 2013, abandoned.
Application 14/951,444 is a continuation of application No. 13/789,575, filed on Mar. 7, 2013.
Claims priority of provisional application 61/636,381, filed on Apr. 20, 2012.
Prior Publication US 2020/0384017 A1, Dec. 10, 2020 Prior Publication US 2022/0347209 A9, Nov. 3, 2022
Int. Cl. A61K 33/24 (2019.01); A61K 9/00 (2006.01); A61K 9/51 (2006.01); A61K 41/00 (2020.01); A61K 9/50 (2006.01); A61K 33/242 (2019.01); A61K 33/243 (2019.01)

CPC A61K 33/242 (2019.01) [A61K 9/0009 (2013.01); A61K 9/0014 (2013.01); A61K 9/50 (2013.01); A61K 9/5115 (2013.01); A61K 33/24 (2013.01); A61K 33/243 (2019.01); A61K 41/0047 (2013.01)]

20 Claims

1. A method of localizing thermal damage to a pilosebaceous unit, the method comprising:

providing a solution of plasmonic gold nanoshells configured for application to a skin surface, wherein the solution comprises:

20% to 73% ethyl alcohol;

1% to 9% polysorbate 80; and

12-65% water or plasmonic gold nanoshells suspended in water,

wherein the plasmonic gold nanoshells are not bound to each other through a physical force or chemical bond either directly or indirectly through an intermediary;

applying the solution of plasmonic gold nanoshells to a skin surface;

targeting the pilosebaceous unit by redistributing the solution of plasmonic gold nanoshells from the skin surface to the pilosebaceous unit,

wherein the plasmonic gold nanoshells induce a surface plasmon upon exposure to an infrared light source for localizing thermal damage to said pilosebaceous unit, wherein the plasmonic gold nanoshells have a diameter of about 150 nm, wherein the plasmonic gold nanoshells have a peak absorption wavelength in a near-infrared range, wherein the plasmonic gold nanoshells have a coating that is less conductive than gold, wherein the coating comprises polyethylene glycol (PEG), wherein the gold and the coating form a metal/dielectric interface; wherein the plasmonic gold nanoshells have a silica core;

selectively removing the solution from the skin surface while leaving the solution localized within the pilosebaceous unit; and

irradiating the solution of plasmonic gold nanoshells with an energy to induce the surface plasmon in said plasmonic gold nanoshells for localizing thermal damage to said pilosebaceous unit.