CPC A61K 31/454 (2013.01) [A61K 31/4015 (2013.01); A61K 31/427 (2013.01); A61K 31/45 (2013.01); A61K 31/517 (2013.01); A61K 31/551 (2013.01); A61K 47/54 (2017.08); A61K 47/545 (2017.08); A61K 47/55 (2017.08)] | 14 Claims |
1. A compound having formula V:
wherein
R3 is selected from the group consisting of hydrogen, halogen, hydroxyl, azide, alkoxyl, sulfhydryl, imino, amido, phosphonate, phosphinate, carbonyl, carboxyl, cyano, silyl, ether, alkylthio, sulfonyl, sulfonamido, ketone, aldehyde, substituted or unsubstituted amine, substituted or unsubstituted amide, nitro, ester, morpholino, dioxolane, substituted or unsubstituted alkyl, substituted or unsubstituted alkylhalide, substituted or unsubstituted aralkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkyl; substituted or unsubstituted heterocyclyl; substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted alkylheteroaryl, and combinations thereof;
R6 and R7 are individually hydrogen, C1-C8 alkyl, or R6 and R7 combine to form ═O; and
L is
wherein n is 1-6, Z is CH or N; R′ is halogen, OH, NHR; and R is aliphatic, aryl, or NO2.
|