US 11,730,726 B2
Dimeric immuno-modulatory compounds against cereblon-based mechanisms
Pearlie Burnette, Tampa, FL (US); Nicholas J. Lawrence, Tampa, FL (US); and Harshani Lawrence, Tampa, FL (US)
Assigned to H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., Tampa, FL (US)
Appl. No. 17/259,005
Filed by H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., Tampa, FL (US)
PCT Filed Jul. 11, 2019, PCT No. PCT/US2019/041413
§ 371(c)(1), (2) Date Jan. 8, 2021,
PCT Pub. No. WO2020/014489, PCT Pub. Date Jan. 16, 2020.
Claims priority of provisional application 62/696,508, filed on Jul. 11, 2018.
Prior Publication US 2022/0362229 A1, Nov. 17, 2022
Int. Cl. A61K 31/454 (2006.01); A61K 47/54 (2017.01); A61K 47/55 (2017.01); A61K 31/4015 (2006.01); A61K 31/427 (2006.01); A61K 31/45 (2006.01); A61K 31/517 (2006.01); A61K 31/551 (2006.01)
CPC A61K 31/454 (2013.01) [A61K 31/4015 (2013.01); A61K 31/427 (2013.01); A61K 31/45 (2013.01); A61K 31/517 (2013.01); A61K 31/551 (2013.01); A61K 47/54 (2017.08); A61K 47/545 (2017.08); A61K 47/55 (2017.08)] 14 Claims
 
1. A compound having formula V:

OG Complex Work Unit Chemistry
wherein
R3 is selected from the group consisting of hydrogen, halogen, hydroxyl, azide, alkoxyl, sulfhydryl, imino, amido, phosphonate, phosphinate, carbonyl, carboxyl, cyano, silyl, ether, alkylthio, sulfonyl, sulfonamido, ketone, aldehyde, substituted or unsubstituted amine, substituted or unsubstituted amide, nitro, ester, morpholino, dioxolane, substituted or unsubstituted alkyl, substituted or unsubstituted alkylhalide, substituted or unsubstituted aralkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkyl; substituted or unsubstituted heterocyclyl; substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted alkylheteroaryl, and combinations thereof;
R6 and R7 are individually hydrogen, C1-C8 alkyl, or R6 and R7 combine to form ═O; and
L is

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
wherein n is 1-6, Z is CH or N; R′ is halogen, OH, NHR; and R is aliphatic, aryl, or NO2.