US 11,730,407 B2
Polymer membranes for continuous analyte sensors
Robert Boock, Carlsbad, CA (US); Monica Rixman Swinney, San Diego, CA (US); Huashi Zhang, San Diego, CA (US); Michael J. Estes, Poway, CA (US); and Kristina Lawrence, Escondido, CA (US)
Assigned to Dexcom, Inc., San Diego, CA (US)
Filed by Dexcom, Inc., San Diego, CA (US)
Filed on Jan. 24, 2022, as Appl. No. 17/583,057.
Application 17/583,057 is a continuation of application No. 17/504,263, filed on Oct. 18, 2021.
Application 17/504,263 is a continuation of application No. 16/177,269, filed on Oct. 31, 2018, granted, now 11,147,483.
Application 16/177,269 is a continuation of application No. 15/611,692, filed on Jun. 1, 2017, granted, now 10,143,410.
Application 15/611,692 is a continuation of application No. 14/742,137, filed on Jun. 17, 2015, granted, now 9,693,721.
Application 14/742,137 is a continuation of application No. 14/517,663, filed on Oct. 17, 2014, granted, now 9,566,026.
Application 14/517,663 is a continuation of application No. 14/058,154, filed on Oct. 18, 2013, granted, now 8,954,128.
Application 14/058,154 is a continuation of application No. 12/718,299, filed on Mar. 5, 2010, granted, now 8,583,204.
Application 12/718,299 is a continuation in part of application No. 12/403,231, filed on Mar. 12, 2009, granted, now 8,090,183.
Claims priority of provisional application 61/040,594, filed on Mar. 28, 2008.
Prior Publication US 2022/0142532 A1, May 12, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/1486 (2006.01); A61B 5/1473 (2006.01); A61B 5/1468 (2006.01); A61B 5/145 (2006.01); G01N 27/40 (2006.01); B33Y 70/00 (2020.01); C12Q 1/00 (2006.01); A61B 5/00 (2006.01)
CPC A61B 5/14865 (2013.01) [A61B 5/1468 (2013.01); A61B 5/1473 (2013.01); A61B 5/1486 (2013.01); A61B 5/14532 (2013.01); A61B 5/14546 (2013.01); C12Q 1/006 (2013.01); G01N 27/40 (2013.01); A61B 5/7203 (2013.01); B33Y 70/00 (2014.12)] 17 Claims
OG exemplary drawing
 
1. A sensor for measurement of an analyte, the sensor comprising:
an in vivo portion configured to be inserted within a body of a host, the in vivo portion comprising:
an electrode configured to measure a signal associated with an analyte concentration in the host; and
a membrane located over at least a portion of the electrode, wherein the membrane comprises an enzyme; and
an ex vivo portion configured to remain outside of the body of the host,
wherein the sensor is configured to be calibrated based on a correlation between an in vivo sensor sensitivity and an in vitro sensor sensitivity;
wherein the sensor is configured to provide, at analyte concentrations of from 40 mg/dL to 400 mg/dL, a level of accuracy corresponding to a mean absolute relative difference of between 7% to 10% over a sensor session of anywhere between 1 to 30 days, and
wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood.