CPC A61B 5/14865 (2013.01) [A61B 5/1468 (2013.01); A61B 5/1473 (2013.01); A61B 5/1486 (2013.01); A61B 5/14532 (2013.01); A61B 5/14546 (2013.01); C12Q 1/006 (2013.01); G01N 27/40 (2013.01); A61B 5/7203 (2013.01); B33Y 70/00 (2014.12)] | 17 Claims |
1. A sensor for measurement of an analyte, the sensor comprising:
an in vivo portion configured to be inserted within a body of a host, the in vivo portion comprising:
an electrode configured to measure a signal associated with an analyte concentration in the host; and
a membrane located over at least a portion of the electrode, wherein the membrane comprises an enzyme; and
an ex vivo portion configured to remain outside of the body of the host,
wherein the sensor is configured to be calibrated based on a correlation between an in vivo sensor sensitivity and an in vitro sensor sensitivity;
wherein the sensor is configured to provide, at analyte concentrations of from 40 mg/dL to 400 mg/dL, a level of accuracy corresponding to a mean absolute relative difference of between 7% to 10% over a sensor session of anywhere between 1 to 30 days, and
wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood.
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