	US 11,728,078 B2
	Magnetic particles and uses thereof
Stephan Hug, Penzberg (DE); Fangbing Liu, Marlborough, MA (US); Nancy Schoenbrunner, Marlborough, MA (US); and Martin Eduardo Silvestre, Penzberg (DE)
Assigned to Roche Molecular Systems, Inc., Pleasanton, CA (US)
Filed by Roche Molecular Systems, Inc., Pleasanton, CA (US)
Filed on Apr. 28, 2020, as Appl. No. 16/860,968.
Application 16/860,968 is a continuation of application No. PCT/EP2018/079829, filed on Oct. 31, 2018.
Claims priority of provisional application 62/579,380, filed on Oct. 31, 2017.
Claims priority of application No. 17199299 (EP), filed on Oct. 31, 2017.
Prior Publication US 2020/0265979 A1, Aug. 20, 2020
Int. Cl. H01F 1/00 (2006.01); H01F 1/34 (2006.01); C01G 49/08 (2006.01); C12N 15/10 (2006.01); C12Q 1/686 (2018.01); H01F 41/02 (2006.01)

CPC H01F 1/344 (2013.01) [C01G 49/08 (2013.01); C12N 15/1013 (2013.01); C12Q 1/686 (2013.01); H01F 1/0018 (2013.01); H01F 41/0206 (2013.01); C01P 2004/03 (2013.01); C01P 2004/62 (2013.01); C01P 2004/86 (2013.01); C01P 2006/42 (2013.01)]

19 Claims

1. A magnetic bead composition comprising (a) a stabilizer and a magnetic core produced under solvothermal conditions and (b) a liquid-glass coating;

wherein the magnetic bead is superparamagnetic,

wherein the magnetic core is a defined aggregate of magnetic nanoparticles, the magnetic nanoparticles having a size of 30 nm or less, and wherein the diameter of the magnetic core is between 100-400 nm, and

wherein the liquid-glass coating comprises a silicate and has a thickness of 20 nm or less.