US 11,728,038 B2
Activity MRI
Charles Springer, Portland, OR (US); Gregory Wilson, Seattle, WA (US); Jeffrey Maki, Seattle, WA (US); Thomas Barbara, Portland, OR (US); Xin Li, Portland, OR (US); William Rooney, Portland, OR (US); Wei Huang, Portland, OR (US); Brendan Moloney, Portland, OR (US); and Eric Baker, Portland, OR (US)
Assigned to OREGON HEALTH & SCIENCE UNIVERSITY, Portland, OR (US)
Appl. No. 16/497,513
Filed by Oregon Health & Science University, Portland, OR (US); and University of Washington, Seattle, WA (US)
PCT Filed Apr. 6, 2018, PCT No. PCT/US2018/026591
§ 371(c)(1), (2) Date Sep. 25, 2019,
PCT Pub. No. WO2018/187768, PCT Pub. Date Oct. 11, 2018.
Claims priority of provisional application 62/482,520, filed on Apr. 6, 2017.
Prior Publication US 2021/0304899 A1, Sep. 30, 2021
Int. Cl. G16H 50/50 (2018.01); G16H 30/20 (2018.01); G01R 33/563 (2006.01)
CPC G16H 50/50 (2018.01) [G01R 33/56341 (2013.01); G16H 30/20 (2018.01)] 27 Claims
OG exemplary drawing
 
18. A computer readable media, comprising a non-transitory, computer-readable storage medium having computer-executable program instructions embodied therein for a method of preparing a parametric tissue map for tissue in a subject, comprising instructions for:
receiving Diffusion-weighted Magnetic Resonance Imaging (D-w MRI) acquisition data comprising a diffusion-weighted 1H2O signal;
determining a b-space decay of one or more voxels in the D-w MRI acquisition data, wherein the b-space decay is a decay of log(S/S0) relative to b, S is a signal intensity of the diffusion-weighted 1H2O signal, S0 is a signal intensity of the diffusion-weighted 1H2O signal immediately after coherence creation, and b is a normalized coherence decay measure; and
selecting a simulated decay of the diffusion-weighted 1H2O signal in b-space from an electronic library of simulated decays of the diffusion-weighted 1H2O signal in b-space that matches the b-space decay of the one or more voxels in the D-w MRI acquisition data, thereby preparing one or more parametric tissue maps of the D-w MRI acquisition data.