US 11,725,217 B2
Methods to enhance myocardial regeneration and/or repair
Daniel J. Garry, Eagan, MN (US); Mary G. Garry, Eagan, MN (US); and Bhairab Singh, Falcon Heights, MN (US)
Assigned to Regents of the University of Minnesota, Minneapolis, MN (US)
Filed by Regents of the University of Minnesota, Minneapolis, MN (US)
Filed on Jul. 23, 2019, as Appl. No. 16/519,889.
Claims priority of provisional application 62/702,743, filed on Jul. 24, 2018.
Prior Publication US 2020/0224218 A1, Jul. 16, 2020
Int. Cl. A61K 48/00 (2006.01); C12N 15/11 (2006.01); C12N 15/12 (2006.01); C12N 15/86 (2006.01); A61P 9/00 (2006.01); C12N 7/00 (2006.01); A61K 31/5377 (2006.01); A61K 35/76 (2015.01)
CPC C12N 15/86 (2013.01) [A61K 31/5377 (2013.01); A61K 35/76 (2013.01); A61P 9/00 (2018.01); C12N 7/00 (2013.01); A61K 48/00 (2013.01); C12N 2740/15042 (2013.01); C12N 2740/15043 (2013.01)] 15 Claims
 
1. A method to enhance repair or regeneration of a mammalian heart in need thereof comprising:
directly administering to the heart of a mammal a composition comprising an effective amount of nucleic acid that encodes Gli1 or Mycn.