CPC C07K 16/34 (2013.01) [C07K 16/2848 (2013.01); G01N 33/6893 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/54 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/70 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); G01N 2333/705 (2013.01); G01N 2800/38 (2013.01)] | 20 Claims |
1. A method of treating fetal and neonatal alloimmune thrombocytopenia (FNAIT) in a fetus of a subject, the method comprising administering to the subject an effective amount of an anti-HPA-1a antibody, wherein the antibody comprises a variable region light chain (VL) comprising:
(a) a VL complementarity determining region (CDR)1 that has the amino acid sequence of SEQ ID NO: 8;
(b) a VL CDR2 that has the amino acid sequence of SEQ ID NO: 9; and
(c) a VL CDR3 that has the amino acid sequence of SEQ ID NO: 10;
and wherein the antibody comprises a variable region heavy chain (VH) comprising:
(d) a VH CDR1 that has the amino acid sequence of SEQ ID NO: 5;
(e) a VH CDR2 that has the amino acid sequence of SEQ ID NO: 6; and
(f) a VH CDR3 that has the amino acid sequence of SEQ ID NO: 7;
wherein the antibody is a full-length IgG antibody, and wherein the subject is an HPA-1a-negative woman.
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