CPC C07K 16/28 (2013.01) [A61P 17/10 (2018.01); A61P 29/00 (2018.01); A61P 35/04 (2018.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/52 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] | 26 Claims |
1. An isolated antibody or antigen-binding fragment thereof that specifically binds to human protease activated receptor 2 (PAR-2) and comprises the heavy chain variable region (VH) complementarity determining region (CDR) 1, VH CDR2, VH CDR3 and light chain variable region (VL) CDR1, VL CDR2, and VL CDR3 sequences of:
(a) SEQ ID NOs: 10, 11, 12, 16, 17, and 18, respectively;
(b) SEQ ID NOs: 7, 8, 9, 13, 14, and 15, respectively;
(c) SEQ ID NOs: 10, 11, 12, 16, 19, and 18, respectively;
(d) SEQ ID NOs: 10, 11, 12, 16, 29, and 18, respectively; or
(e) SEQ ID NOs: 10, 11, 12, 16, 22, and 18, respectively.
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