US 11,725,006 B2
Hydrophilic berberine-type derivative and application thereof in preparing drug
Hailin Qin, Beijing (CN); Lianqiu Wu, Beijing (CN); Xiang Li, Beijing (CN); Haijing Zhang, Beijing (CN); Li Song, Beijing (CN); Huachen Song, Beijing (CN); Anjun Deng, Beijing (CN); Xiaonan Tang, Beijing (CN); Zhihui Zhang, Beijing (CN); Xiang Li, Beijing (CN); and Zhihong Li, Beijing (CN)
Assigned to INSTITUTE OF MATERIA MEDIC, CHINESE ACADEMY OF MEDICAL SCIENCES, Beijing (CN)
Appl. No. 17/46,927
Filed by INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES, Beijing (CN)
PCT Filed Oct. 17, 2019, PCT No. PCT/CN2019/082701
§ 371(c)(1), (2) Date Oct. 12, 2020,
PCT Pub. No. WO2019/196957, PCT Pub. Date Oct. 17, 2019.
Claims priority of application No. 201810328506.3 (CN), filed on Apr. 13, 2018; application No. 201810328605.1 (CN), filed on Apr. 13, 2018; application No. 201810328741.0 (CN), filed on Apr. 13, 2018; application No. 201810328743.X (CN), filed on Apr. 13, 2018; and application No. 201810328797.6 (CN), filed on Apr. 13, 2018.
Prior Publication US 2021/0147409 A1, May 20, 2021
Int. Cl. C07D 455/03 (2006.01); A61P 31/04 (2006.01); A61P 29/00 (2006.01); A61P 1/04 (2006.01); A61P 31/10 (2006.01); A61P 35/00 (2006.01); C07D 493/14 (2006.01); C07D 493/22 (2006.01)
CPC C07D 455/03 (2013.01) [A61P 1/04 (2018.01); A61P 29/00 (2018.01); A61P 31/04 (2018.01); A61P 31/10 (2018.01); A61P 35/00 (2018.01); C07D 493/14 (2013.01); C07D 493/22 (2013.01)] 11 Claims
 
1. An 8-dihalomethyl berberine-type quaternary ammonium salt compound of quaternized imine-type structure shown as general formula I:

OG Complex Work Unit Chemistry
wherein:
R2 and R3 are linked to form alkylene-dioxy;
X1 and X2 are each selected, independently, from F, Cl, Br, or I;
R9 and R10 are linked to form alkylene-dioxy and R11 is H; and
XA is monovalent acid radical ion.