US 11,724,988 B2
Processes
Daniel Schwizer, Bubendorf (CH); Sascha Breeger, Bubendorf (CH); Stephen Thom, Nottingham (GB); and Thomas Alanine, Nottingham (GB)
Assigned to INFLAZOME LIMITED, Dublin (IE)
Appl. No. 17/286,380
Filed by INFLAZOME LIMITED, Dublin (IE)
PCT Filed Oct. 18, 2019, PCT No. PCT/EP2019/078325
§ 371(c)(1), (2) Date Apr. 16, 2021,
PCT Pub. No. WO2020/079207, PCT Pub. Date Apr. 23, 2020.
Claims priority of application No. 1817038.1 (GB), filed on Oct. 19, 2018.
Prior Publication US 2022/0064125 A1, Mar. 3, 2022
Int. Cl. C07D 231/08 (2006.01); C07C 209/36 (2006.01)
CPC C07D 231/08 (2013.01) [C07C 209/36 (2013.01); C07C 2603/10 (2017.05)] 11 Claims
 
1. A process of preparing N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1-isopropyl-1H-pyrazole-3-sulfonamide or a salt thereof, comprising the step of contacting 1-isopropyl-3-(alkoxycarbonylaminosulfonyl)-1H-pyrazole with 1,2,3,5,6,7-hexahydro-s-indacen-4-amine in the presence of a solvent to obtain N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1-isopropyl-1H-pyrazole-3-sulfonamide:

OG Complex Work Unit Chemistry
wherein R is C1-6 alkyl.